منابع مشابه
Antiproliferative Activity of β-Hydroxy-β-Arylalkanoic Acids
Article describes the synthesis of fifteen β-hydroxy-β-arylalkanoic acids by Reformatsky reaction using the 1-ethoxyethyl-2-bromoalkanoates, aromatic or cycloalkyl ketones or aromatic aldehydes. The short survey of previously reported synthetic procedures for title compounds, is given. The majority of obtained compounds exert antiproliferative activity in vitro toward human: HeLa, Fem-X cells, ...
متن کاملSYNTHESIS OF a-AMINO-p-HYDROXY-n-BUTYRIC ACIDS VII. AN IMPROVED SYNTHESIS OF DL-ALLOTHREONINE
Several methods are available for the synthesis of DL-threonine (l-3). However, each of these involves the separation of threonine from a mixture containing varying proportions of the isomeric allothreonine. Recently it has been reported that derivatives of rm-allothreonine may be converted to DL-threonine in excellent yields (3-5). These developments make the preparation of nn-allothreonine of...
متن کاملConversion of the methionine hydroxy analogue DL-2-hydroxy-(4-methylthio) butanoic acid to sulfur-containing amino acids in the chicken small intestine.
dl-Methionine or its corresponding hydroxy analogue, DL-2-hydroxy-(4-methylthio) butanoic acid (DLHMB), are commonly added to commercial animal diets to satisfy the TSAA requirement. The utilization of DLHMB as a supplementary source of Met begins with its conversion to L-Met via a 2-step mediated process. L-Methionine can then be transsulfurated to L-Cys, which, in turn, can be catabolized to ...
متن کاملDocking Studies and α-Substitution Effects on the Anti-Inflammatory Activity of β-Hydroxy-β-arylpropanoic Acids.
Six β-hydroxy-β-aryl propanoic acids were synthesised using a modification of Reformatsky reaction which has already been reported. These acids belong to the aryl propanoic acid class of compounds, structurally similar to the NSAIDs, such as ibuprofen, and an anti-inflammatory activity is thus expected. The aim of this work was to determine anti-inflammatory activity, examine gastric tolerabili...
متن کاملEfficacy of DL-methionine hydroxy analog free acid and DL-methionine as methionine sources for pigs.
Two experiments were conducted to evaluate the efficacy of dietary DL-methionine hydroxy analog-free acid (MHA-FA, 88%) compared with DL-methionine (DLM, 99%) as Met sources in pigs. In Exp. 1, a total of 245 crossbred pigs (initial BW of 6.4 kg [SD = 0.5]) were allotted to 7 treatments in 7 replicates for an experimental period of 28 d. The basal diet (BD) was formulated to contain 17.5% CP an...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1953
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)71380-x